Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle
by Scott S. Terhune, Yongwoon Jung, Katie M. Cataldo, Ranjan K. Dash
The cellular protein-protein interaction network that governs cellular proliferation (cell cycle) is highly complex. Here, we have developed a novel computational model of human mitotic cell cycle, integrating diverse cellular mechanisms, for the purpose of generating new hypotheses and predicting new experiments designed to help understand complex diseases. The pathogenic state investigated is infection by a human herpesvirus. Читать дальше...
