'Northwest Passage' mechanism of bile acid transport reveals a voltage-dependent pathway

In a study published in Nature on January 28, a research team led by Eric H. Xu (Xu Huaqiang) from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, along with Ma Xiong from Renji Hospital, determined how Ostα/β transports bile acids and why it differs fundamentally from previously characterized carriers through cryo-EM structure determination, molecular dynamics simulations, and electrophysiological analyses.