Efficient algorithms to discover alterations with complementary functional association in cancer
by Rebecca Sarto Basso, Dorit S. Hochbaum, Fabio Vandin
Recent large cancer studies have measured somatic alterations in an unprecedented number of tumours. These large datasets allow the identification of cancer-related sets of genetic alterations by identifying relevant combinatorial patterns. Among such patterns, mutual exclusivity has been employed by several recent methods that have shown its effectiveness in characterizing gene sets associated to cancer. Mutual exclusivity arises because of the complementarity... Читать дальше...