Serie A official line-ups: Lecce vs. Roma
Roma are forced to revamp their defence with Daniele Ghilardi, while Niccolò Pisilli gets a rare start alongside Paulo Dybala and Evan Ferguson against Lecce.
It kicks off at the Stadio Via del Mare at 17.00 GMT (16.00 CET).
The Giallorossi are still smarting after the controversial 1-0 defeat to Atalanta, but above all Gian Piero Gasperini has a decimated squad.
Both Gianluca Mancini and Mario Hermoso are suspended, with Evan Ndicka and Neil El Aynaoui still at the Africa Cup of Nations.
Lorenzo Pellegrini, Leon Bailey, Tommaso Baldanzi and Pierluigi Gollini are injured and did not make the trip.
Devyne Rensch was a late addition to the absentee list after coming down with flu.
It means Ghilardi and Pisilli get rare starts, while Stephan El Shaarawy has to fill in on the left flank as a makeshift wingback, and Bryan Cristante pushed into a more advanced role.
Ferguson is still trying to prove he deserves to stay at Roma amid reports he’ll be sent back to Brighton, and is supported by Dybala.
Matias Soulé and Artem Dovbyk are not at 100 per cent.
Lecce coach Eusebio Di Francesco is in the stands to complete his two-match ban for dissent, but he watched his team earn a surprise 1-1 draw away to Juventus at the weekend.
They clambered out of the drop zone recently with victories over Parma, Fiorentina, Torino and Pisa.
Lassana Coulibaly is at AFCON, with Tete Morente, Medon Berisha, Balthazar Pierret and Christian Fruchtl injured, but Riccardo Sottil is available again.
It will always be a special game for lifelong Roma supporter Wladimiro Falcone in goal.
Danilo Veiga returns to the starting XI at right-back.
Lecce vs. Roma line-ups
Lecce: Falcone; Danilo Veiga, Gaspar, Tiago Gabriel, Gallo; Drame, Ramadani, Maleh; Sottil, Camarda, Banda
Roma: Svilar; Celik, Ziolkowski, Ghilardi; Wesley, Koné, Pisilli, El Shaarawy; Dybala, Cristante; Ferguson