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Сентябрь
2020

Новости за 24.09.2020

Effects of long-term in vivo micro-CT imaging on hallmarks of osteopenia and frailty in aging mice

Plos.org 

by Ariane C. Scheuren, Gisela A. Kuhn, Ralph Müller

In vivo micro-CT has already been used to monitor microstructural changes of bone in mice of different ages and in models of age-related diseases such as osteoporosis. However, as aging is accompanied by frailty and subsequent increased sensitivity to external stimuli such as handling and anesthesia, the extent to which longitudinal imaging can be applied in aging studies remains unclear. Consequently, the potential of monitoring individual... Читать дальше...



Continuous pressure measurement and serial micro–computed tomography analysis during injection laryngoplasty: A preliminary canine cadaveric study

Plos.org 

by Min-Su Kim, Seongmin An, Songwan Jin, Taehoen Kim, Tack-Kyun Kwon

Injection laryngoplasty (IL) has been used to treat various types of glottal insufficiency. The precise volume and location of the injected materials impact the outcomes. However, exactly how increasing volumes of material are distributed is unknown. In fact, the amount of IL material required to medialize a vocal cord tends to be determined empirically. Thus, the goal of this study was to investigate the pattern of IL material... Читать дальше...

Familial Alzheimer’s disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system

Plos.org 

by Christian Tackenberg, Luka Kulic, Roger M. Nitsch

Familial forms of Alzheimer’s disease (AD) are caused by mutations in the presenilin genes or in the gene encoding for the amyloid precursor protein (APP). Proteolytic cleavage of APP generates the β-amyloid peptide (Aβ), which aggregates into amyloid plaques, one of the major hallmarks of AD. APP mutations within the Aβ sequence, so-called intra-Aβ mutations, cluster around position E693 of APP, which corresponds to position E22 in the Aβ sequence. Читать дальше...



Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes

Plos.org 

by Prasanna M. Chandramouleeswaran, Manti Guha, Masataka Shimonosono, Kelly A. Whelan, Hisatsugu Maekawa, Uma M. Sachdeva, Gordon Ruthel, Sarmistha Mukherjee, Noah Engel, Michael V. Gonzalez, James Garifallou, Shinya Ohashi, Andres J. Klein-Szanto, Clementina A. Mesaros, Ian A. Blair, Renata Pellegrino da Silva, Hakon Hakonarson, Eishi Noguchi, Joseph A. Baur, Hiroshi Nakagawa

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Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission

Plos.org 

by Tyler Jones, Naava Naslavsky, Steve Caplan

Upon internalization, receptors are trafficked to sorting endosomes (SE) where they undergo sorting and are then packaged into budding vesicles that undergo fission and transport within the cell. Eps15 Homology Domain Protein 1 (EHD1), the best-characterized member of the Eps15 Homology Domain Protein (EHD) family, has been implicated in catalyzing the fission process that releases endosome-derived vesicles for recycling to the plasma membrane. Читать дальше...


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Dendritic integration in olfactory bulb granule cells upon simultaneous multispine activation: Low thresholds for nonlocal spiking activity

Plos.org 

by Max Mueller, Veronica Egger

The inhibitory axonless olfactory bulb granule cells form reciprocal dendrodendritic synapses with mitral and tufted cells via large spines, mediating recurrent and lateral inhibition. As a case in point for dendritic transmitter release, rat granule cell dendrites are highly excitable, featuring local Na+ spine spikes and global Ca2+- and Na+-spikes. To investigate the transition from local to global signaling, we performed holographic, simultaneous 2-photon... Читать дальше...

Everything Points To More Natural Gas Demand This Decade

Oilprice.com 

Natural gas has often been vilified as just another fossil fuel contributing to the climate crisis.  While gas-fired power generation and the natural gas value chain do emit greenhouse gases, natural gas burns cleaner than other fossil fuels, most notably coal, and can play a major role in replacing coal-fired power generation, immediately contributing to lower emissions from the electricity sector.     Natural gas also has an important role to play in helping power grids with flexible and reliable... Читать дальше...

16 | The Moment Residential Building / Pi architects

Archdaily.com 

The subject of the project was the designing of a residential unit of approximately 300 square meters area for the parents of a family, and four units of 150 square meters area for children and a possible surplus in the construction license on a 510 square meter land for sale.

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