Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels
by Jérémie Scire, Nathanaël Hozé, Hildegard Uecker
Antimicrobial resistance is one of the major public health threats of the 21st century. There is a pressing need to adopt more efficient treatment strategies in order to prevent the emergence and spread of resistant strains. The common approach is to treat patients with high drug doses, both to clear the infection quickly and to reduce the risk of de novo resistance. Recently, several studies have argued that, at least in some cases, low-dose... Читать дальше...
